Assay Detail
Functional
CHEMBL2184383
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Cytotoxicity against human 786-0 cells expressing HIF2alpha after 2 days by XTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 786-0 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.72 | 4.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2177350 | NEOPETROFORMYNE A | — | 1 | 4.84 |
| CHEMBL2177349 | HALICLONADIAMINE | — | 1 | 4.82 |
| CHEMBL157844 | PUUPEHENONE | — | 1 | 4.75 |
| CHEMBL2177348 | — | — | 1 | 4.47 |
| CHEMBL380500 | VARIOLIN B | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2177350 | NEOPETROFORMYNE A | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL2177349 | HALICLONADIAMINE | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL157844 | PUUPEHENONE | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL2177348 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL380500 | VARIOLIN B | IC50 | > | 100000.0 | nM | - |