Assay Detail
Functional
CHEMBL2184466
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human P2X3 receptor by cell-based calcium influx assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.69 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180149 | — | — | 1 | 6.37 |
| CHEMBL2180137 | — | — | 1 | 5.00 |
| CHEMBL2180138 | — | — | 1 | - |
| CHEMBL2180136 | — | — | 1 | - |
| CHEMBL2180174 | — | — | 1 | - |
| CHEMBL2180171 | — | — | 1 | - |
| CHEMBL2180160 | — | — | 1 | - |
| CHEMBL1163419 | TNP-ATP | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180149 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL2180137 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2180138 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2180136 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2180174 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL2180171 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2180160 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1163419 | TNP-ATP | IC50 | - | — | - |