Assay Detail
Functional
CHEMBL2184469
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at mouse P2X4 receptor by cell-based calcium influx assay
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.68 | 5.89 |
| EC50 | 2 | 5.50 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | 2.0 | 1 | 6.00 |
| CHEMBL1163419 | TNP-ATP | — | 1 | 5.89 |
| CHEMBL2180137 | — | — | 1 | 5.75 |
| CHEMBL2180160 | — | — | 1 | 5.75 |
| CHEMBL2180149 | — | — | 1 | 5.58 |
| CHEMBL2180174 | — | — | 1 | 5.57 |
| CHEMBL2180138 | — | — | 1 | 5.55 |
| CHEMBL336208 | — | — | 1 | 5.00 |
| CHEMBL2180136 | — | — | 1 | - |
| CHEMBL2180171 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1163419 | TNP-ATP | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL2180137 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL2180160 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL2180149 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL2180174 | — | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL2180138 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL336208 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2180136 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2180171 | — | IC50 | > | 10000.0 | nM | - |