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Assay Detail

CHEMBL2184607

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Phototoxicity in 2.5 J/cm'2 UV-A irradiated human MCF7 cells after 72 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Pyrrolo[3,4-h]quinolinones a new class of photochemotherapeutic agents.
Barraja P, Diana P, Montalbano A, Carbone A, Viola G, Basso G, Salvador A, Vedaldi D, Dall'Acqua F, Cirrincione G.
Bioorg Med Chem (2011) 19 : 2326 -2341
PubMed 21397509 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.34 5.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2181072 1 5.77
CHEMBL2181074 1 5.60
CHEMBL2181062 1 5.48
CHEMBL53569 ANGELICIN 1 5.36
CHEMBL2181069 1 5.18
CHEMBL2181075 1 5.00
CHEMBL2181061 1 5.00
CHEMBL2181073 1 -
CHEMBL2181071 1 -
CHEMBL2181070 1 -
CHEMBL2181068 1 -
CHEMBL2181067 1 -
CHEMBL2181066 1 -
CHEMBL2181065 1 -
CHEMBL2181064 1 -
CHEMBL2181063 1 -
CHEMBL2177144 1 -
CHEMBL2181078 1 -
CHEMBL2181077 1 -
CHEMBL2181076 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2181072 IC50 = 1700.0 nM 5.77
CHEMBL2181074 IC50 = 2500.0 nM 5.60
CHEMBL2181062 IC50 = 3300.0 nM 5.48
CHEMBL53569 ANGELICIN IC50 = 4400.0 nM 5.36
CHEMBL2181069 IC50 = 6600.0 nM 5.18
CHEMBL2181075 IC50 = 10000.0 nM 5.00
CHEMBL2181061 IC50 = 10000.0 nM 5.00
CHEMBL2181073 IC50 > 20000.0 nM -
CHEMBL2181071 IC50 > 20000.0 nM -
CHEMBL2181070 IC50 > 20000.0 nM -
CHEMBL2181068 IC50 > 20000.0 nM -
CHEMBL2181067 IC50 > 20000.0 nM -
CHEMBL2181066 IC50 > 20000.0 nM -
CHEMBL2181065 IC50 > 20000.0 nM -
CHEMBL2181064 IC50 > 20000.0 nM -
CHEMBL2181063 IC50 > 20000.0 nM -
CHEMBL2177144 IC50 > 20000.0 nM -
CHEMBL2181078 IC50 > 20000.0 nM -
CHEMBL2181077 IC50 > 20000.0 nM -
CHEMBL2181076 IC50 > 20000.0 nM -