Assay Detail
Binding
CHEMBL2184780
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Competitive inhibition of PIM1 in presence of ATP
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potential use of selective and nonselective Pim kinase inhibitors for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.16 | 8.15 |
| Ki | 1 | 7.62 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1952329 | SGI-1776 | 1.0 | 1 | 8.15 |
| CHEMBL183906 | — | — | 1 | 7.62 |
| CHEMBL391586 | — | — | 1 | 7.30 |
| CHEMBL493937 | — | — | 1 | 7.24 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1952329 | SGI-1776 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL183906 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL391586 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL493937 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL50 | QUERCETIN | IC50 | = | 1100.0 | nM | 5.96 |