Assay Detail
Binding
CHEMBL2184801
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Irreversible inhibition of constitutive 20S proteasome subunit beta5 chymotrypsin-like activity in human WM cells using suc-LLVY-amc as substrate after 2 hrs by fluorescence assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | WM |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Molecular mechanisms of acquired proteasome inhibitor resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.00 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103884 | OPROZOMIB | 2.0 | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103884 | OPROZOMIB | IC50 | = | 10.0 | nM | 8.00 |