Assay Detail
Binding
CHEMBL2184802
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta1 after 30 mins by fluorogenic assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Molecular mechanisms of acquired proteasome inhibitor resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.05 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2141296 | IXAZOMIB | 3.0 | 1 | 7.51 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.28 |
| CHEMBL371405 | MARIZOMIB | 3.0 | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2141296 | IXAZOMIB | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL371405 | MARIZOMIB | IC50 | = | 430.0 | nM | 6.37 |