Assay Detail
Binding
CHEMBL2185049
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Inhibition of HDAC6 by fluorometric assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.65 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.68 |
| CHEMBL2178343 | — | — | 1 | 5.96 |
| CHEMBL2178342 | — | — | 1 | 5.62 |
| CHEMBL2178344 | — | — | 1 | 5.50 |
| CHEMBL2178345 | — | — | 1 | 5.10 |
| CHEMBL2170177 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2178343 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2178342 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2178344 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2178345 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL2170177 | — | IC50 | = | 9300.0 | nM | 5.03 |