Assay Detail
Binding
CHEMBL2185053
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Inhibition of HDAC1 by fluorometric assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.13 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.57 |
| CHEMBL2178342 | — | — | 1 | 4.42 |
| CHEMBL2178345 | — | — | 1 | 4.39 |
| CHEMBL2178343 | — | — | 1 | - |
| CHEMBL2178344 | — | — | 1 | - |
| CHEMBL2170177 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2178342 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL2178345 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL2178343 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2178344 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2170177 | — | IC50 | > | 100000.0 | nM | - |