Assay Detail
ADMET
CHEMBL2185054
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Cytotoxicity against human MRC5 SV2 cells after 72 hrs by resazurin fluorimetric analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.50 | 4.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219777 | — | — | 1 | 4.50 |
| CHEMBL2180996 | — | — | 1 | 4.49 |
| CHEMBL327844 | — | — | 1 | - |
| CHEMBL29292 | UBENIMEX | 2.0 | 1 | - |
| CHEMBL2180997 | — | — | 1 | - |
| CHEMBL572368 | — | — | 1 | - |
| CHEMBL2180994 | — | — | 1 | - |
| CHEMBL2180993 | — | — | 1 | - |
| CHEMBL2180992 | — | — | 1 | - |
| CHEMBL2180991 | — | — | 1 | - |
| CHEMBL219618 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219777 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL2180996 | — | IC50 | = | 32200.0 | nM | 4.49 |
| CHEMBL327844 | — | IC50 | - | — | - | |
| CHEMBL29292 | UBENIMEX | IC50 | - | — | - | |
| CHEMBL2180997 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL572368 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2180994 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2180993 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2180992 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL2180991 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL219618 | — | IC50 | > | 64000.0 | nM | - |