Assay Detail
Functional
CHEMBL2185076
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Cytotoxicity against human MDA-MB-231 cells after 96 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.10 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2181000 | — | — | 1 | 7.80 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.43 |
| CHEMBL2180999 | — | — | 1 | 7.07 |
| CHEMBL2181009 | — | — | 1 | 7.05 |
| CHEMBL2181002 | — | — | 1 | 7.04 |
| CHEMBL2181004 | — | — | 1 | 7.03 |
| CHEMBL2181001 | — | — | 1 | 6.28 |
| CHEMBL2181003 | — | — | 1 | - |
| CHEMBL2181008 | — | — | 1 | - |
| CHEMBL2181007 | — | — | 1 | - |
| CHEMBL2181006 | — | — | 1 | - |
| CHEMBL2181005 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2181000 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL107 | COLCHICINE | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2180999 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL2181009 | — | IC50 | = | 89.1 | nM | 7.05 |
| CHEMBL2181002 | — | IC50 | = | 92.2 | nM | 7.04 |
| CHEMBL2181004 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL2181001 | — | IC50 | = | 523.0 | nM | 6.28 |
| CHEMBL2181003 | — | IC50 | - | — | - | |
| CHEMBL2181008 | — | IC50 | - | — | - | |
| CHEMBL2181007 | — | IC50 | - | — | - | |
| CHEMBL2181006 | — | IC50 | - | — | - | |
| CHEMBL2181005 | — | IC50 | - | — | - |