Assay Detail
Functional
CHEMBL2185176
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human nAChR alpha6/alpha3beta2beta3 V273S mutant expressed in HEK293T cells by FLIPR
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.84 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2177538 | — | — | 1 | 7.85 |
| CHEMBL2177537 | — | — | 1 | 7.82 |
| CHEMBL2177545 | — | — | 1 | - |
| CHEMBL2177544 | — | — | 1 | - |
| CHEMBL2177543 | — | — | 1 | - |
| CHEMBL2177540 | — | — | 1 | - |
| CHEMBL2177539 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2177538 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2177537 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2177545 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2177544 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2177543 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2177540 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2177539 | — | EC50 | > | 10000.0 | nM | - |