Assay Detail
Functional
CHEMBL2185356
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Cytotoxicity against human CA46 cells after 24 hrs by MTS assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CA46 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anticancer activity and cellular repression of c-MYC by the G-quadruplex-stabilizing 11-piperazinylquindoline is not dependent on direct targeting of the G-quadruplex in the c-MYC promoter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.09 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178559 | — | — | 1 | 5.55 |
| CHEMBL222252 | — | — | 1 | 5.00 |
| CHEMBL2178565 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178559 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL222252 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2178565 | — | IC50 | = | 19400.0 | nM | 4.71 |