Assay Detail
Binding
CHEMBL2185449
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Displacement of biotinylated-TM PAA from Escherichia coli FimH expressed in Escherichia coli HM125 after 3 hrs by colorimetry
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Target Selectivity of FimH Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.67 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1852052 | — | — | 1 | 8.17 |
| CHEMBL1852236 | — | — | 1 | 7.77 |
| CHEMBL2079375 | — | — | 1 | 7.70 |
| CHEMBL2177628 | — | — | 1 | 7.51 |
| CHEMBL1170455 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1852052 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL1852236 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2079375 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2177628 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1170455 | — | IC50 | = | 65.0 | nM | 7.19 |