Assay Detail
Functional
CHEMBL2185486
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Cytotoxicity against human HEY cells incubated for 72 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEY |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.30 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180567 | — | — | 1 | 6.00 |
| CHEMBL2180246 | — | — | 1 | 6.00 |
| CHEMBL2180561 | — | — | 1 | 5.40 |
| CHEMBL2180562 | — | — | 1 | 5.40 |
| CHEMBL2180568 | — | — | 1 | 5.30 |
| CHEMBL2180247 | — | — | 1 | 5.28 |
| CHEMBL2180564 | — | — | 1 | 5.28 |
| CHEMBL2180245 | — | — | 1 | 5.22 |
| CHEMBL2180565 | — | — | 1 | 5.16 |
| CHEMBL2180249 | — | — | 1 | 5.15 |
| CHEMBL2180560 | — | — | 1 | 5.10 |
| CHEMBL2180566 | — | — | 1 | 5.05 |
| CHEMBL2180243 | — | — | 1 | 4.96 |
| CHEMBL2180569 | — | — | 1 | 4.92 |
| CHEMBL2180584 | — | — | 1 | - |
| CHEMBL2180563 | — | — | 1 | - |
| CHEMBL2180570 | — | — | 1 | - |
| CHEMBL2180244 | — | — | 1 | - |
| CHEMBL2180248 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180567 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2180246 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2180561 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2180562 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2180568 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2180247 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL2180564 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL2180245 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2180565 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2180249 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL2180560 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2180566 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL2180243 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2180569 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2180584 | — | IC50 | - | — | - | |
| CHEMBL2180563 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2180570 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2180244 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL2180248 | — | IC50 | > | 20000.0 | nM | - |