Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2185493

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human SKBR3 cells incubated for 72 hrs by MTT assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-BR-3
Confidence 1 — Organism
Curated By Autocuration

Target

SK-BR-3 (CHEMBL613834)
Type CELL-LINE
Organism Homo sapiens

Publication

Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.
Zeng LF, Wang Y, Kazemi R, Xu S, Xu ZL, Sanchez TW, Yang LM, Debnath B, Odde S, Xie H, Zheng YT, Ding J, Neamati N, Long YQ.
J Med Chem (2012) 55 : 9492 -9509
PubMed 23098137 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 34 5.50 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2180582 1 6.00
CHEMBL2180577 1 6.00
CHEMBL2180574 1 6.00
CHEMBL2180576 1 6.00
CHEMBL2180575 1 6.00
CHEMBL2180581 1 6.00
CHEMBL2180567 1 5.70
CHEMBL2180584 1 5.70
CHEMBL2180246 1 5.70
CHEMBL2180249 1 5.55
CHEMBL2180578 1 5.52
CHEMBL2180583 1 5.52
CHEMBL2180579 1 5.40
CHEMBL2180247 1 5.38
CHEMBL2180561 1 5.30
CHEMBL2180568 1 5.22
CHEMBL2177139 1 5.22
CHEMBL2180562 1 5.22
CHEMBL2180565 1 5.22
CHEMBL2180245 1 5.16
CHEMBL2180560 1 5.10
CHEMBL2180559 1 5.07
CHEMBL2180563 1 5.05
CHEMBL2180570 1 5.00
CHEMBL2180573 1 -
CHEMBL2180598 1 -
CHEMBL2180580 1 -
CHEMBL2180558 1 -
CHEMBL2180564 1 -
CHEMBL2180566 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2180582 IC50 = 1000.0 nM 6.00
CHEMBL2180581 IC50 = 1000.0 nM 6.00
CHEMBL2180575 IC50 = 1000.0 nM 6.00
CHEMBL2180576 IC50 = 1000.0 nM 6.00
CHEMBL2180574 IC50 = 1000.0 nM 6.00
CHEMBL2180577 IC50 = 1000.0 nM 6.00
CHEMBL2180246 IC50 = 2000.0 nM 5.70
CHEMBL2180584 IC50 = 2000.0 nM 5.70
CHEMBL2180567 IC50 = 2000.0 nM 5.70
CHEMBL2180249 IC50 = 2800.0 nM 5.55
CHEMBL2180578 IC50 = 3000.0 nM 5.52
CHEMBL2180583 IC50 = 3000.0 nM 5.52
CHEMBL2180579 IC50 = 4000.0 nM 5.40
CHEMBL2180247 IC50 = 4200.0 nM 5.38
CHEMBL2180561 IC50 = 5000.0 nM 5.30
CHEMBL2177139 IC50 = 6000.0 nM 5.22
CHEMBL2180562 IC50 = 6000.0 nM 5.22
CHEMBL2180568 IC50 = 6000.0 nM 5.22
CHEMBL2180565 IC50 = 6000.0 nM 5.22
CHEMBL2180245 IC50 = 7000.0 nM 5.16
CHEMBL2180560 IC50 = 8000.0 nM 5.10
CHEMBL2180559 IC50 = 8500.0 nM 5.07
CHEMBL2180563 IC50 = 9000.0 nM 5.05
CHEMBL2180570 IC50 = 10000.0 nM 5.00
CHEMBL2180248 IC50 - -
CHEMBL2180244 IC50 - -
CHEMBL2180243 IC50 - -
CHEMBL2180569 IC50 - -
CHEMBL2180566 IC50 - -
CHEMBL2180564 IC50 - -
CHEMBL2180558 IC50 > 10000.0 nM -
CHEMBL2180580 IC50 > 10000.0 nM -
CHEMBL2180598 IC50 - -
CHEMBL2180573 IC50 > 10000.0 nM -