Assay Detail
Binding
CHEMBL2185500
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Inhibition of HIV1 integrase strand transfer activity using [32P]-labeled linear oligonucleotide substrate
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.93 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180591 | — | — | 1 | 6.70 |
| CHEMBL2180587 | — | — | 1 | 6.70 |
| CHEMBL414850 | — | — | 1 | 6.52 |
| CHEMBL2180589 | — | — | 1 | 6.52 |
| CHEMBL2180590 | — | — | 1 | 6.52 |
| CHEMBL2180599 | — | — | 1 | 6.30 |
| CHEMBL2180586 | — | — | 1 | 6.16 |
| CHEMBL2180585 | — | — | 1 | 6.16 |
| CHEMBL2180588 | — | — | 1 | 6.00 |
| CHEMBL2180600 | — | — | 1 | 4.89 |
| CHEMBL2180601 | — | — | 1 | 4.51 |
| CHEMBL2180593 | — | — | 1 | 4.16 |
| CHEMBL2180594 | — | — | 1 | - |
| CHEMBL2180592 | — | — | 1 | - |
| CHEMBL2180595 | — | — | 1 | - |
| CHEMBL2180596 | — | — | 1 | - |
| CHEMBL2180597 | — | — | 1 | - |
| CHEMBL2180598 | — | — | 1 | - |
| CHEMBL2180571 | — | — | 1 | - |
| CHEMBL2180572 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180591 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2180587 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL414850 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2180589 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2180590 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2180599 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2180586 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2180585 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2180588 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2180600 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2180601 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL2180593 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL2180594 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2180592 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2180595 | — | IC50 | > | 111000.0 | nM | - |
| CHEMBL2180596 | — | IC50 | > | 111000.0 | nM | - |
| CHEMBL2180597 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2180598 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2180571 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2180572 | — | IC50 | > | 100000.0 | nM | - |