Assay Detail
Binding
CHEMBL2185579
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human cathepsin D
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based design of highly selective β-secretase inhibitors: synthesis, biological evaluation, and protein-ligand X-ray crystal structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.62 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2179138 | — | — | 1 | 6.28 |
| CHEMBL2179137 | — | — | 1 | 6.16 |
| CHEMBL2179140 | — | — | 1 | 5.70 |
| CHEMBL2179131 | — | — | 1 | 5.37 |
| CHEMBL2179136 | — | — | 1 | 5.15 |
| CHEMBL2179130 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2179138 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL2179137 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL2179140 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL2179131 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL2179136 | — | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL2179130 | — | Ki | = | 8264.0 | nM | 5.08 |