Assay Detail
Binding
CHEMBL2185582
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BACE1 in human neuroblastoma cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based design of highly selective β-secretase inhibitors: synthesis, biological evaluation, and protein-ligand X-ray crystal structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.16 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2179131 | — | — | 1 | 9.00 |
| CHEMBL403268 | — | — | 1 | 8.60 |
| CHEMBL2179130 | — | — | 1 | 8.02 |
| CHEMBL2179140 | — | — | 1 | 7.85 |
| CHEMBL2179138 | — | — | 1 | 7.82 |
| CHEMBL2179136 | — | — | 1 | 7.66 |
| CHEMBL2179132 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2179131 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL403268 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL2179130 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL2179140 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2179138 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2179136 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2179132 | — | IC50 | > | 1000.0 | nM | - |