Assay Detail
Functional
CHEMBL2185906
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Cytotoxicity against human MIAPaCa2 cells after 72 hrs by coulter counter analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation (in vitro and in vivo) of cyclic arginine-glycine-aspartate (RGD) peptidomimetic-paclitaxel conjugates targeting integrin αVβ3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.56 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180983 | — | — | 1 | 8.74 |
| CHEMBL2180985 | — | — | 1 | 8.70 |
| CHEMBL2180984 | — | — | 1 | 8.64 |
| CHEMBL2180982 | — | — | 1 | 8.60 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.14 |
| CHEMBL2180981 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180983 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL2180985 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2180984 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL2180982 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL2180981 | — | IC50 | > | 11600.0 | nM | - |