Assay Detail
Binding
CHEMBL2185949
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Mixed type inhibition of Trypanosoma brucei TR using varying levels of trypanothione disulfide assessed as inhibition constant for enzyme-inhibitor complex by Lineweaver-Burk plot
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Trypanothione reductase (CHEMBL1837) ↗| Type | SINGLE PROTEIN |
| Organism | Trypanosoma brucei brucei |
Publication
Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 5.51 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178999 | — | — | 1 | 5.55 |
| CHEMBL2179000 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178999 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL2179000 | — | Ki | = | 3400.0 | nM | 5.47 |