Assay Detail
Binding
CHEMBL2186306
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant mTOR (1360 to 2549 amino acids) assessed as reduction in phosphorylation of (GFP)-4-EBP1 after 30 mins by FRET assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinase α.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.83 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178608 | — | — | 1 | 8.05 |
| CHEMBL2178606 | — | — | 1 | 8.00 |
| CHEMBL2178613 | — | — | 1 | 7.89 |
| CHEMBL2178614 | — | — | 1 | 7.68 |
| CHEMBL1084926 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178608 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL2178606 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL2178613 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL2178614 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL1084926 | — | Ki | = | 30.0 | nM | 7.52 |