Assay Detail
Functional
CHEMBL2186429
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Antitrypanosomal activity against promastigote form of Leishmania donovani MHOM/SD/00/1S-2D assessed as growth inhibition after 72 hrs by inverted microscopy
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.26 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256155 | — | — | 1 | 6.13 |
| CHEMBL255731 | — | — | 1 | 5.55 |
| CHEMBL2177124 | — | — | 1 | 5.45 |
| CHEMBL2179000 | — | — | 1 | 5.44 |
| CHEMBL2178999 | — | — | 1 | 5.11 |
| CHEMBL2178998 | — | — | 1 | 5.06 |
| CHEMBL2179005 | — | — | 1 | 5.04 |
| CHEMBL2179006 | — | — | 1 | 4.81 |
| CHEMBL2179004 | — | — | 1 | 4.79 |
| CHEMBL2179003 | — | — | 1 | - |
| CHEMBL2179002 | — | — | 1 | - |
| CHEMBL2179001 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256155 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL255731 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL2177124 | — | IC50 | = | 3590.0 | nM | 5.45 |
| CHEMBL2179000 | — | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL2178999 | — | IC50 | = | 7720.0 | nM | 5.11 |
| CHEMBL2178998 | — | IC50 | = | 8720.0 | nM | 5.06 |
| CHEMBL2179005 | — | IC50 | = | 9080.0 | nM | 5.04 |
| CHEMBL2179006 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL2179004 | — | IC50 | = | 16060.0 | nM | 4.79 |
| CHEMBL2179003 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2179002 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2179001 | — | IC50 | > | 30000.0 | nM | - |