Assay Detail
Binding
CHEMBL2186560
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Displacement of [3H]di-o-tolylguanidine from Sigma2 receptor in rat liver homogenate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
New positron emission tomography (PET) radioligand for imaging σ-1 receptors in living subjects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.73 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.24 |
| CHEMBL272899 | — | — | 1 | 6.61 |
| CHEMBL2181924 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 57.2 | nM | 7.24 |
| CHEMBL272899 | — | Ki | = | 247.0 | nM | 6.61 |
| CHEMBL2181924 | — | Ki | = | 467.0 | nM | 6.33 |