Assay Detail
Binding
CHEMBL2186596
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Inhibition of purified JAK2 incubated for 30 mins
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 8.45 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178804 | — | — | 1 | 10.00 |
| CHEMBL2178805 | — | — | 1 | 10.00 |
| CHEMBL1789941 | RUXOLITINIB | 4.0 | 1 | 9.62 |
| CHEMBL2178803 | — | — | 1 | 9.52 |
| CHEMBL2178801 | — | — | 1 | 9.52 |
| CHEMBL2178799 | — | — | 1 | 9.40 |
| CHEMBL2178800 | — | — | 1 | 9.22 |
| CHEMBL2178258 | — | — | 1 | 9.00 |
| CHEMBL2178254 | — | — | 1 | 9.00 |
| CHEMBL2178255 | — | — | 1 | 8.89 |
| CHEMBL2178802 | — | — | 1 | 8.80 |
| CHEMBL2178257 | — | — | 1 | 8.74 |
| CHEMBL2178266 | — | — | 1 | 8.68 |
| CHEMBL2178807 | — | — | 1 | 8.60 |
| CHEMBL2178253 | — | — | 1 | 8.49 |
| CHEMBL2178252 | — | — | 1 | 8.49 |
| CHEMBL2178247 | — | — | 1 | 8.29 |
| CHEMBL2177122 | — | — | 1 | 8.28 |
| CHEMBL2178260 | — | — | 1 | 8.25 |
| CHEMBL2178249 | — | — | 1 | 8.15 |
| CHEMBL2178250 | — | — | 1 | 8.01 |
| CHEMBL2178806 | — | — | 1 | 7.92 |
| CHEMBL2178261 | — | — | 1 | 7.85 |
| CHEMBL2178248 | — | — | 1 | 7.81 |
| CHEMBL2178263 | — | — | 1 | 7.78 |
| CHEMBL2178256 | — | — | 1 | 7.50 |
| CHEMBL2178262 | — | — | 1 | 7.39 |
| CHEMBL2178264 | — | — | 1 | 7.38 |
| CHEMBL2178259 | — | — | 1 | 7.31 |
| CHEMBL2178265 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178804 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL2178805 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL1789941 | RUXOLITINIB | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL2178803 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL2178801 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL2178799 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL2178800 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL2178258 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL2178254 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL2178255 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL2178802 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL2178257 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL2178266 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL2178807 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL2178253 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL2178252 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL2178247 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL2177122 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL2178260 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL2178249 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL2178250 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL2178806 | — | Ki | = | 11.9 | nM | 7.92 |
| CHEMBL2178261 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL2178248 | — | Ki | = | 15.5 | nM | 7.81 |
| CHEMBL2178263 | — | Ki | = | 16.7 | nM | 7.78 |
| CHEMBL2178256 | — | Ki | = | 31.9 | nM | 7.50 |
| CHEMBL2178262 | — | Ki | = | 41.1 | nM | 7.39 |
| CHEMBL2178264 | — | Ki | = | 41.2 | nM | 7.38 |
| CHEMBL2178259 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL2178265 | — | Ki | = | 63.3 | nM | 7.20 |
| CHEMBL2178251 | — | Ki | = | 103.0 | nM | 6.99 |