Assay Detail
Binding
CHEMBL2186603
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK2 in human TF1 cells assessed as reduction in STAT5 phosphorylation incubated for 30 mins in presence of human recombinant EPO
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | TF-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.51 | 8.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1789941 | RUXOLITINIB | 4.0 | 1 | 8.16 |
| CHEMBL2178804 | — | — | 1 | 8.13 |
| CHEMBL2178805 | — | — | 1 | 8.01 |
| CHEMBL2178801 | — | — | 1 | 7.65 |
| CHEMBL2178800 | — | — | 1 | 7.46 |
| CHEMBL2178803 | — | — | 1 | 7.39 |
| CHEMBL2178799 | — | — | 1 | 7.37 |
| CHEMBL2178266 | — | — | 1 | 7.19 |
| CHEMBL2178802 | — | — | 1 | 7.16 |
| CHEMBL2177122 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1789941 | RUXOLITINIB | IC50 | = | 6.85 | nM | 8.16 |
| CHEMBL2178804 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL2178805 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL2178801 | — | IC50 | = | 22.4 | nM | 7.65 |
| CHEMBL2178800 | — | IC50 | = | 34.5 | nM | 7.46 |
| CHEMBL2178803 | — | IC50 | = | 40.4 | nM | 7.39 |
| CHEMBL2178799 | — | IC50 | = | 42.3 | nM | 7.37 |
| CHEMBL2178266 | — | IC50 | = | 64.2 | nM | 7.19 |
| CHEMBL2178802 | — | IC50 | = | 68.6 | nM | 7.16 |
| CHEMBL2177122 | — | IC50 | = | 242.0 | nM | 6.62 |