Assay Detail
Functional
CHEMBL2186855
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human K562 cells expressing wild type Bcr-Abl after 72 hrs by CCK-8 assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of 3-(1H-1,2,3-triazol-1-yl)benzamide derivatives as Potent Pan Bcr-Abl inhibitors including the threonine(315)→isoleucine(315) mutant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 8.68 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178278 | — | — | 1 | 9.64 |
| CHEMBL2178276 | — | — | 1 | 9.62 |
| CHEMBL2178271 | — | — | 1 | 9.60 |
| CHEMBL2177649 | — | — | 1 | 9.51 |
| CHEMBL2177648 | — | — | 1 | 9.49 |
| CHEMBL2177646 | — | — | 1 | 9.41 |
| CHEMBL2177645 | — | — | 1 | 9.40 |
| CHEMBL2177642 | — | — | 1 | 9.38 |
| CHEMBL2178277 | — | — | 1 | 9.37 |
| CHEMBL1214141 | — | — | 1 | 9.36 |
| CHEMBL2177632 | — | — | 1 | 9.20 |
| CHEMBL2177647 | — | — | 1 | 9.18 |
| CHEMBL2178275 | — | — | 1 | 9.17 |
| CHEMBL2177634 | — | — | 1 | 9.17 |
| CHEMBL2178270 | — | — | 1 | 9.17 |
| CHEMBL2178268 | — | — | 1 | 9.10 |
| CHEMBL2178279 | — | — | 1 | 9.07 |
| CHEMBL2177633 | — | — | 1 | 9.07 |
| CHEMBL2177636 | — | — | 1 | 8.91 |
| CHEMBL2178269 | — | — | 1 | 8.90 |
| CHEMBL2177635 | — | — | 1 | 8.90 |
| CHEMBL2177631 | — | — | 1 | 8.61 |
| CHEMBL2178274 | — | — | 1 | 8.54 |
| CHEMBL2177650 | — | — | 1 | 8.49 |
| CHEMBL2178267 | — | — | 1 | 8.47 |
| CHEMBL2178272 | — | — | 1 | 8.47 |
| CHEMBL2178273 | — | — | 1 | 8.46 |
| CHEMBL2177630 | — | — | 1 | 8.41 |
| CHEMBL2178280 | — | — | 1 | 8.24 |
| CHEMBL2177638 | — | — | 1 | 8.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178278 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL2178276 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL2178271 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL2177649 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL2177648 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL2177646 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL2177645 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2177642 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL2178277 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL1214141 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL2177632 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL2177647 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL2178275 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL2177634 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL2178270 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL2178268 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL2178279 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL2177633 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL2177636 | — | IC50 | = | 1.24 | nM | 8.91 |
| CHEMBL2178269 | — | IC50 | = | 1.25 | nM | 8.90 |
| CHEMBL2177635 | — | IC50 | = | 1.26 | nM | 8.90 |
| CHEMBL2177631 | — | IC50 | = | 2.45 | nM | 8.61 |
| CHEMBL2178274 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL2177650 | — | IC50 | = | 3.22 | nM | 8.49 |
| CHEMBL2178267 | — | IC50 | = | 3.41 | nM | 8.47 |
| CHEMBL2178272 | — | IC50 | = | 3.37 | nM | 8.47 |
| CHEMBL2178273 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL2177630 | — | IC50 | = | 3.87 | nM | 8.41 |
| CHEMBL2178280 | — | IC50 | = | 5.69 | nM | 8.24 |
| CHEMBL2177638 | — | IC50 | = | 7.04 | nM | 8.15 |
| CHEMBL2177637 | — | IC50 | = | 7.26 | nM | 8.14 |
| CHEMBL2177639 | — | IC50 | = | 8.82 | nM | 8.05 |
| CHEMBL2177644 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL2177629 | — | IC50 | = | 35.8 | nM | 7.45 |
| CHEMBL2177641 | — | IC50 | = | 40.9 | nM | 7.39 |
| CHEMBL2177643 | — | IC50 | = | 70.4 | nM | 7.15 |
| CHEMBL2178281 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL2177640 | — | IC50 | = | 798.0 | nM | 6.10 |