Assay Detail
Functional
CHEMBL2186946
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Cytostatic activity against mouse L1210/0 cells after 48 hrs by cell counting
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210/0 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 7.42 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL917 | FLOXURIDINE | 4.0 | 1 | 9.05 |
| CHEMBL2181358 | — | — | 1 | 8.68 |
| CHEMBL2181359 | — | — | 1 | 8.49 |
| CHEMBL2181357 | — | — | 1 | 8.02 |
| CHEMBL2181360 | — | — | 1 | 7.96 |
| CHEMBL2181367 | FOSIFLOXURIDINE NAFALBENAMIDE | 2.0 | 1 | 7.96 |
| CHEMBL2181364 | — | — | 1 | 7.92 |
| CHEMBL2181365 | — | — | 1 | 7.85 |
| CHEMBL2181560 | — | — | 1 | 7.80 |
| CHEMBL2181361 | — | — | 1 | 7.80 |
| CHEMBL2181355 | — | — | 1 | 7.72 |
| CHEMBL2181374 | — | — | 1 | 7.68 |
| CHEMBL2181556 | — | — | 1 | 7.58 |
| CHEMBL2181566 | — | — | 1 | 7.55 |
| CHEMBL2181371 | — | — | 1 | 7.54 |
| CHEMBL2181565 | — | — | 1 | 7.54 |
| CHEMBL2181356 | — | — | 1 | 7.52 |
| CHEMBL2181564 | — | — | 1 | 7.52 |
| CHEMBL2181373 | — | — | 1 | 7.52 |
| CHEMBL2181370 | — | — | 1 | 7.51 |
| CHEMBL2181555 | — | — | 1 | 7.50 |
| CHEMBL2181362 | — | — | 1 | 7.44 |
| CHEMBL2181366 | — | — | 1 | 7.41 |
| CHEMBL2046836 | — | — | 1 | 7.40 |
| CHEMBL2181368 | — | — | 1 | 7.39 |
| CHEMBL2181354 | — | — | 1 | 7.35 |
| CHEMBL2181554 | — | — | 1 | 7.30 |
| CHEMBL2181375 | — | — | 1 | 7.27 |
| CHEMBL2181558 | — | — | 1 | 7.27 |
| CHEMBL2181376 | — | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL917 | FLOXURIDINE | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL2181358 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL2181359 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL2181357 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL2181360 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2181367 | FOSIFLOXURIDINE NAFALBENAMIDE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2181364 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2181365 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2181560 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2181361 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2181355 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2181374 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2181556 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2181566 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2181565 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2181371 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2181356 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2181564 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2181373 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2181370 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2181555 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2181362 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2181366 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2046836 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2181368 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2181354 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2181554 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2181375 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL2181558 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL2181376 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL2181562 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL2181363 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL2181553 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2181561 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2181557 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2177147 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2181563 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2181372 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL2181559 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL2181369 | — | IC50 | = | 1200.0 | nM | 5.92 |