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Assay Detail

CHEMBL2186947

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Functional
Cytostatic activity against thymidine-kinase deficient mouse L1210 cells after 48 hrs by cell counting
ChEMBL ↗
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Autocuration

Target

L1210 (CHEMBL386) ↗
Type CELL-LINE
Organism Mus musculus

Publication

Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.
McGuigan C, Murziani P, Slusarczyk M, Gonczy B, Vande Voorde J, Liekens S, Balzarini J.
J Med Chem (2011) 54 : 7247 -7258
PubMed 21892829 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 41 5.89 7.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2181367 FOSIFLOXURIDINE NAFALBENAMIDE 2.0 1 7.35
CHEMBL2181364 — — 1 7.21
CHEMBL2181359 — — 1 7.12
CHEMBL2181360 — — 1 7.06
CHEMBL2181357 — — 1 6.96
CHEMBL2181365 — — 1 6.92
CHEMBL2181355 — — 1 6.89
CHEMBL2181358 — — 1 6.89
CHEMBL2181361 — — 1 6.89
CHEMBL2181555 — — 1 6.85
CHEMBL2181362 — — 1 6.82
CHEMBL2181356 — — 1 6.80
CHEMBL2181565 — — 1 6.75
CHEMBL2181354 — — 1 6.52
CHEMBL185 FLUOROURACIL 4.0 1 6.50
CHEMBL2181566 — — 1 6.44
CHEMBL2181376 — — 1 6.09
CHEMBL2181553 — — 1 6.03
CHEMBL2181559 — — 1 5.96
CHEMBL2181554 — — 1 5.96
CHEMBL2181370 — — 1 5.92
CHEMBL2181363 — — 1 5.92
CHEMBL2181371 — — 1 5.82
CHEMBL2181375 — — 1 5.72
CHEMBL2181558 — — 1 5.70
CHEMBL2181561 — — 1 5.66
CHEMBL2181373 — — 1 5.54
CHEMBL917 FLOXURIDINE 4.0 1 5.52
CHEMBL2181562 — — 1 5.39
CHEMBL2181564 — — 1 5.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2181367 FOSIFLOXURIDINE NAFALBENAMIDE IC50 = 45.0 nM 7.35
CHEMBL2181364 — IC50 = 62.0 nM 7.21
CHEMBL2181359 — IC50 = 76.0 nM 7.12
CHEMBL2181360 — IC50 = 88.0 nM 7.06
CHEMBL2181357 — IC50 = 110.0 nM 6.96
CHEMBL2181365 — IC50 = 120.0 nM 6.92
CHEMBL2181355 — IC50 = 130.0 nM 6.89
CHEMBL2181358 — IC50 = 130.0 nM 6.89
CHEMBL2181361 — IC50 = 130.0 nM 6.89
CHEMBL2181555 — IC50 = 140.0 nM 6.85
CHEMBL2181362 — IC50 = 150.0 nM 6.82
CHEMBL2181356 — IC50 = 160.0 nM 6.80
CHEMBL2181565 — IC50 = 180.0 nM 6.75
CHEMBL2181354 — IC50 = 300.0 nM 6.52
CHEMBL185 FLUOROURACIL IC50 = 320.0 nM 6.50
CHEMBL2181566 — IC50 = 360.0 nM 6.44
CHEMBL2181376 — IC50 = 820.0 nM 6.09
CHEMBL2181553 — IC50 = 940.0 nM 6.03
CHEMBL2181559 — IC50 = 1100.0 nM 5.96
CHEMBL2181554 — IC50 = 1100.0 nM 5.96
CHEMBL2181370 — IC50 = 1200.0 nM 5.92
CHEMBL2181363 — IC50 = 1200.0 nM 5.92
CHEMBL2181371 — IC50 = 1500.0 nM 5.82
CHEMBL2181375 — IC50 = 1900.0 nM 5.72
CHEMBL2181558 — IC50 = 2000.0 nM 5.70
CHEMBL2181561 — IC50 = 2200.0 nM 5.66
CHEMBL2181373 — IC50 = 2900.0 nM 5.54
CHEMBL917 FLOXURIDINE IC50 = 3000.0 nM 5.52
CHEMBL2181562 — IC50 = 4100.0 nM 5.39
CHEMBL2181564 — IC50 = 4600.0 nM 5.34
CHEMBL2181374 — IC50 = 5600.0 nM 5.25
CHEMBL2181372 — IC50 = 12000.0 nM 4.92
CHEMBL2181556 — IC50 = 13000.0 nM 4.89
CHEMBL2177147 — IC50 = 25000.0 nM 4.60
CHEMBL2181368 — IC50 = 27000.0 nM 4.57
CHEMBL2181563 — IC50 = 31000.0 nM 4.51
CHEMBL2181369 — IC50 = 35000.0 nM 4.46
CHEMBL2181560 — IC50 = 39000.0 nM 4.41
CHEMBL2181366 — IC50 = 40000.0 nM 4.40
CHEMBL2046836 — IC50 = 41000.0 nM 4.39
CHEMBL2181557 — IC50 = 42000.0 nM 4.38