Assay Detail
Functional
CHEMBL2187313
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Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 infected in human RBCs after 72 hrs by parasite lactate dehydrogenase assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.57 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2181217 | — | — | 1 | 7.96 |
| CHEMBL2181207 | — | — | 1 | 7.68 |
| CHEMBL2181215 | — | — | 1 | 7.68 |
| CHEMBL2181214 | — | — | 1 | 7.64 |
| CHEMBL1630 | — | — | 1 | 7.60 |
| CHEMBL147587 | ISOQUINE | — | 1 | 7.57 |
| CHEMBL2181213 | — | — | 1 | 7.51 |
| CHEMBL2181216 | — | — | 1 | 7.42 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.32 |
| CHEMBL2181208 | — | — | 1 | 7.28 |
| CHEMBL2181212 | — | — | 1 | - |
| CHEMBL2181211 | — | — | 1 | - |
| CHEMBL2181210 | — | — | 1 | - |
| CHEMBL2181209 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2181217 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2181207 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2181215 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2181214 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1630 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL147587 | ISOQUINE | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2181213 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2181216 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL2181208 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL2181212 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2181211 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2181210 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2181209 | — | IC50 | > | 1000.0 | nM | - |