Assay Detail
Binding
CHEMBL2187458
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant PDE10A1 expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 30 mins by liquid scintillation counting
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf21 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (CHEMBL4409) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Current landscape of phosphodiesterase 10A (PDE10A) inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.24 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2069321 | — | — | 1 | 9.55 |
| CHEMBL2180775 | — | — | 1 | 9.15 |
| CHEMBL2070666 | — | — | 1 | 8.83 |
| CHEMBL2070659 | — | — | 1 | 8.45 |
| CHEMBL1086110 | — | — | 1 | 8.15 |
| CHEMBL1085374 | — | — | 1 | 8.15 |
| CHEMBL2180773 | — | — | 1 | 8.02 |
| CHEMBL2180771 | — | — | 1 | 7.62 |
| CHEMBL2180774 | — | — | 1 | 7.34 |
| CHEMBL2180772 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2069321 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL2180775 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL2070666 | — | IC50 | = | 1.48 | nM | 8.83 |
| CHEMBL2070659 | — | IC50 | = | 3.55 | nM | 8.45 |
| CHEMBL1086110 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1085374 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2180773 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL2180771 | — | IC50 | = | 23.7 | nM | 7.62 |
| CHEMBL2180774 | — | IC50 | = | 45.5 | nM | 7.34 |
| CHEMBL2180772 | — | IC50 | = | 77.2 | nM | 7.11 |