Assay Detail
Functional
CHEMBL2187459
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at alpha6/alpha3beta2beta3 nAChR in Sprague-Dawley rat striatal synaptosomes assessed as induction of dopamine release
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Nicotinic acetylcholine receptor alpha6/alpha3/beta2/beta3 (CHEMBL3137275) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.02 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2177538 | — | — | 1 | 9.02 |
| CHEMBL2177537 | — | — | 1 | 8.85 |
| CHEMBL2177545 | — | — | 1 | 6.14 |
| CHEMBL2177539 | — | — | 1 | 6.07 |
| CHEMBL2177544 | — | — | 1 | 6.06 |
| CHEMBL2177543 | — | — | 1 | 5.96 |
| CHEMBL2177540 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2177538 | — | EC50 | = | 0.95 | nM | 9.02 |
| CHEMBL2177537 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2177545 | — | EC50 | = | 718.0 | nM | 6.14 |
| CHEMBL2177539 | — | EC50 | = | 855.0 | nM | 6.07 |
| CHEMBL2177544 | — | EC50 | = | 879.0 | nM | 6.06 |
| CHEMBL2177543 | — | EC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL2177540 | — | EC50 | > | 10000.0 | nM | - |