Assay Detail
Functional
CHEMBL2187462
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat alpha7 nAChR T6'S59 mutant expressed in rat GH4C1 cells by whole cell voltage clamp based electrophysiology method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | GH4-C1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.08 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2177537 | — | — | 1 | 7.70 |
| CHEMBL2177538 | — | — | 1 | 7.52 |
| CHEMBL2177545 | — | — | 1 | 6.46 |
| CHEMBL2177543 | — | — | 1 | 5.55 |
| CHEMBL2177540 | — | — | 1 | 5.42 |
| CHEMBL2177539 | — | — | 1 | 5.22 |
| CHEMBL2177544 | — | — | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2177537 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2177538 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2177545 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2177543 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2177540 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL2177539 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2177544 | — | EC50 | = | 21300.0 | nM | 4.67 |