Assay Detail
Binding
CHEMBL2187476
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]epibatidine from human alpha7 nAChR expressed in human HEK/RIC3 cells
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK/RIC3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 53 | 7.07 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2177538 | — | — | 1 | 8.92 |
| CHEMBL2177537 | — | — | 1 | 8.89 |
| CHEMBL2177512 | — | — | 1 | 8.80 |
| CHEMBL2177553 | — | — | 1 | 8.80 |
| CHEMBL2177552 | — | — | 1 | 8.48 |
| CHEMBL2177551 | — | — | 1 | 8.44 |
| CHEMBL2177536 | — | — | 1 | 8.40 |
| CHEMBL2177541 | — | — | 1 | 8.34 |
| CHEMBL2177514 | — | — | 1 | 8.14 |
| CHEMBL2178160 | — | — | 1 | 7.89 |
| CHEMBL2178157 | — | — | 1 | 7.89 |
| CHEMBL2177555 | — | — | 1 | 7.82 |
| CHEMBL2177546 | — | — | 1 | 7.77 |
| CHEMBL2177518 | — | — | 1 | 7.72 |
| CHEMBL2177522 | — | — | 1 | 7.70 |
| CHEMBL2177545 | — | — | 1 | 7.66 |
| CHEMBL2177513 | — | — | 1 | 7.64 |
| CHEMBL2178159 | — | — | 1 | 7.64 |
| CHEMBL2177109 | — | — | 1 | 7.52 |
| CHEMBL2177530 | — | — | 1 | 7.48 |
| CHEMBL2178158 | — | — | 1 | 7.41 |
| CHEMBL2177524 | — | — | 1 | 7.41 |
| CHEMBL2177547 | — | — | 1 | 7.36 |
| CHEMBL2177539 | — | — | 1 | 7.16 |
| CHEMBL2178156 | — | — | 1 | 7.14 |
| CHEMBL2177540 | — | — | 1 | 7.13 |
| CHEMBL2177516 | — | — | 1 | 7.11 |
| CHEMBL2177535 | — | — | 1 | 7.10 |
| CHEMBL2177528 | — | — | 1 | 7.10 |
| CHEMBL2177543 | — | — | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2177538 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL2177537 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL2177553 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL2177512 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL2177552 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL2177551 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL2177536 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL2177541 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL2177514 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL2178160 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL2178157 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL2177555 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL2177546 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL2177518 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL2177522 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL2177545 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL2177513 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL2178159 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL2177109 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL2177530 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL2178158 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL2177524 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL2177547 | — | Ki | = | 43.9 | nM | 7.36 |
| CHEMBL2177539 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL2178156 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL2177540 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL2177516 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL2177535 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL2177528 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL2177543 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL2177549 | — | Ki | = | 111.4 | nM | 6.95 |
| CHEMBL2178155 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL2177517 | — | Ki | = | 281.0 | nM | 6.55 |
| CHEMBL2177521 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL2177529 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL2177542 | — | Ki | = | 605.0 | nM | 6.22 |
| CHEMBL2177533 | — | Ki | = | 641.0 | nM | 6.19 |
| CHEMBL2177554 | — | Ki | = | 1007.0 | nM | 6.00 |
| CHEMBL2177523 | — | Ki | = | 1305.0 | nM | 5.88 |
| CHEMBL2177531 | — | Ki | = | 1421.0 | nM | 5.85 |
| CHEMBL2177526 | — | Ki | = | 1849.0 | nM | 5.73 |
| CHEMBL2177532 | — | Ki | = | 3220.0 | nM | 5.49 |
| CHEMBL2177548 | — | Ki | = | 4545.0 | nM | 5.34 |
| CHEMBL2177520 | — | Ki | = | 4847.0 | nM | 5.32 |
| CHEMBL2177525 | — | Ki | = | 6530.0 | nM | 5.18 |
| CHEMBL2177550 | — | Ki | = | 7565.0 | nM | 5.12 |
| CHEMBL2178154 | — | Ki | = | 8006.0 | nM | 5.10 |
| CHEMBL132966 | RIVANICLINE | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL2177544 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2177527 | — | Ki | > | 10000.0 | nM | - |