Assay Detail
Binding
CHEMBL2187568
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Plasmodium falciparum DHODH expressed in Escherichia coli BL21 (DE3) using L-dihydroorotate as substrate after 10 mins by DCIP dye reduction assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (CHEMBL3486) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
Discovery of diverse human dihydroorotate dehydrogenase inhibitors as immunosuppressive agents by structure-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.42 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178108 | — | — | 1 | 6.12 |
| CHEMBL2178105 | — | — | 1 | 5.71 |
| CHEMBL2178109 | — | — | 1 | 5.33 |
| CHEMBL222556 | — | — | 1 | 5.02 |
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178108 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL2178105 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL2178109 | — | IC50 | = | 4670.0 | nM | 5.33 |
| CHEMBL222556 | — | IC50 | = | 9480.0 | nM | 5.02 |
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 11390.0 | nM | 4.94 |