Assay Detail
Binding
CHEMBL2187569
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Inhibition of human DHODH expressed in Escherichia coli BL21(DE3) using L-dihydroorotate as substrate after 10 mins by DCIP dye reduction assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of diverse human dihydroorotate dehydrogenase inhibitors as immunosuppressive agents by structure-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.58 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178104 | — | — | 1 | 6.96 |
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | 6.89 |
| CHEMBL2178105 | — | — | 1 | 6.47 |
| CHEMBL2178106 | — | — | 1 | 6.26 |
| CHEMBL2178107 | — | — | 1 | 6.11 |
| CHEMBL2178108 | — | — | 1 | 6.03 |
| CHEMBL2177115 | — | — | 1 | 5.90 |
| CHEMBL2178109 | — | — | 1 | 5.74 |
| CHEMBL2178110 | — | — | 1 | 5.56 |
| CHEMBL1076869 | — | — | 1 | 5.48 |
| CHEMBL2178111 | — | — | 1 | 5.40 |
| CHEMBL2178112 | — | — | 1 | 5.22 |
| CHEMBL1373924 | — | — | 1 | 5.17 |
| CHEMBL222556 | — | — | 1 | 4.91 |
| CHEMBL2177491 | — | — | 1 | 4.89 |
| CHEMBL2177492 | — | — | 1 | 4.81 |
| CHEMBL2177493 | — | — | 1 | 4.79 |
| CHEMBL2177494 | — | — | 1 | 4.75 |
| CHEMBL2177495 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178104 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2178105 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL2178106 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL2178107 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL2178108 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL2177115 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL2178109 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL2178110 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL1076869 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2178111 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL2178112 | — | IC50 | = | 6060.0 | nM | 5.22 |
| CHEMBL1373924 | — | IC50 | = | 6830.0 | nM | 5.17 |
| CHEMBL222556 | — | IC50 | = | 12380.0 | nM | 4.91 |
| CHEMBL2177491 | — | IC50 | = | 13010.0 | nM | 4.89 |
| CHEMBL2177492 | — | IC50 | = | 15620.0 | nM | 4.81 |
| CHEMBL2177493 | — | IC50 | = | 16080.0 | nM | 4.79 |
| CHEMBL2177494 | — | IC50 | = | 17750.0 | nM | 4.75 |
| CHEMBL2177495 | — | IC50 | = | 18280.0 | nM | 4.74 |