Assay Detail
Functional
CHEMBL2187899
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Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced IL6 production
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.46 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2017288 | — | — | 1 | 7.00 |
| CHEMBL2017285 | — | — | 1 | 7.00 |
| CHEMBL2017281 | — | — | 1 | 7.00 |
| CHEMBL2017291 | — | — | 1 | 6.70 |
| CHEMBL2017286 | — | — | 1 | 6.50 |
| CHEMBL2017273 | — | — | 1 | 6.30 |
| CHEMBL2181820 | — | — | 1 | 6.10 |
| CHEMBL2017277 | — | — | 1 | 6.00 |
| CHEMBL2017269 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2017288 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2017285 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2017281 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2017291 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL2017286 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL2017273 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL2181820 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL2017277 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2017269 | — | IC50 | = | 3162.28 | nM | 5.50 |