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Assay Detail

CHEMBL2187912

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of thiazene red from amyloid beta (1 to 40) aggregate
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and β-amyloid plaques in Alzheimer's disease models.
Boländer A, Kieser D, Voss C, Bauer S, Schön C, Burgold S, Bittner T, Hölzer J, Heyny-von Haußen R, Mall G, Goetschy V, Czech C, Knust H, Berger R, Herms J, Hilger I, Schmidt B.
J Med Chem (2012) 55 : 9170 -9180
PubMed 22913544 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.69 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2181533 1 8.52
CHEMBL2181039 1 7.77
CHEMBL2181041 1 7.37
CHEMBL2181042 1 7.29
CHEMBL2181532 1 7.28
CHEMBL2181045 1 7.27
CHEMBL2181036 1 6.85
CHEMBL2181531 1 6.81
CHEMBL2181047 1 5.62
CHEMBL2181537 1 5.34
CHEMBL2181535 1 5.12
CHEMBL2181538 1 5.00
CHEMBL2181046 1 -
CHEMBL2181534 1 -
CHEMBL2181044 1 -
CHEMBL2181043 1 -
CHEMBL2181536 1 -
CHEMBL2181040 1 -
CHEMBL2181038 1 -
CHEMBL2181037 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2181533 IC50 = 3.0 nM 8.52
CHEMBL2181039 IC50 = 17.0 nM 7.77
CHEMBL2181041 IC50 = 43.0 nM 7.37
CHEMBL2181042 IC50 = 51.0 nM 7.29
CHEMBL2181532 IC50 = 52.0 nM 7.28
CHEMBL2181045 IC50 = 54.0 nM 7.27
CHEMBL2181036 IC50 = 140.0 nM 6.85
CHEMBL2181531 IC50 = 156.0 nM 6.81
CHEMBL2181047 IC50 = 2381.0 nM 5.62
CHEMBL2181537 IC50 = 4571.0 nM 5.34
CHEMBL2181535 IC50 = 7591.0 nM 5.12
CHEMBL2181538 IC50 = 10066.0 nM 5.00
CHEMBL2181046 IC50 - -
CHEMBL2181534 IC50 - -
CHEMBL2181044 IC50 - -
CHEMBL2181043 IC50 - -
CHEMBL2181536 IC50 - -
CHEMBL2181040 IC50 - -
CHEMBL2181038 IC50 - -
CHEMBL2181037 IC50 - -