Assay Detail
Binding
CHEMBL2187944
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant MAOA assessed as H2O2 production by Amplex Red reagent-based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multitarget-directed benzylideneindanone derivatives: anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.20 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 8.39 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 6.16 |
| CHEMBL2177466 | — | — | 1 | 4.45 |
| CHEMBL2177467 | — | — | 1 | 4.42 |
| CHEMBL2177464 | — | — | 1 | 4.42 |
| CHEMBL2177465 | — | — | 1 | 4.38 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 4.15 |
| CHEMBL255231 | LADOSTIGIL | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL887 | RASAGILINE | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2177466 | — | IC50 | = | 35200.0 | nM | 4.45 |
| CHEMBL2177467 | — | IC50 | = | 37700.0 | nM | 4.42 |
| CHEMBL2177464 | — | IC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL2177465 | — | IC50 | = | 41400.0 | nM | 4.38 |
| CHEMBL972 | SELEGILINE | IC50 | = | 70200.0 | nM | 4.15 |
| CHEMBL255231 | LADOSTIGIL | IC50 | - | — | - |