Assay Detail
Binding
CHEMBL2187945
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Inhibition of human recombinant MAOB assessed as H2O2 production by Amplex Red reagent-based assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multitarget-directed benzylideneindanone derivatives: anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.38 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 7.85 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 7.73 |
| CHEMBL2177467 | — | — | 1 | 5.12 |
| CHEMBL2177465 | — | — | 1 | 5.11 |
| CHEMBL2177466 | — | — | 1 | 4.97 |
| CHEMBL2177464 | — | — | 1 | 4.96 |
| CHEMBL2177457 | — | — | 1 | 4.73 |
| CHEMBL2177462 | — | — | 1 | 4.54 |
| CHEMBL255231 | LADOSTIGIL | 2.0 | 1 | 4.43 |
| CHEMBL2177463 | — | — | 1 | 4.39 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL972 | SELEGILINE | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL2177467 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL2177465 | — | IC50 | = | 7710.0 | nM | 5.11 |
| CHEMBL2177466 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL2177464 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL2177457 | — | IC50 | = | 18550.0 | nM | 4.73 |
| CHEMBL2177462 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL255231 | LADOSTIGIL | IC50 | = | 37100.0 | nM | 4.43 |
| CHEMBL2177463 | — | IC50 | = | 40500.0 | nM | 4.39 |
| CHEMBL8706 | CLORGILINE | IC50 | - | — | - |