Assay Detail
Binding
CHEMBL2188143
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Inhibition of Staphylococcus aureus recombinant FabI using trans-2-octenoyl N-acetylcysteamine thioester as substrate preincubated for 60 mins
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI (CHEMBL3994) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
From triclosan toward the clinic: discovery of nonbiocidal, potent FabI inhibitors for the treatment of resistant bacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.27 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178304 | — | — | 1 | 8.10 |
| CHEMBL2178284 | — | — | 1 | 7.92 |
| CHEMBL2178291 | — | — | 1 | 7.89 |
| CHEMBL2178287 | — | — | 1 | 7.80 |
| CHEMBL2178286 | — | — | 1 | 7.55 |
| CHEMBL2178305 | — | — | 1 | 7.51 |
| CHEMBL2178303 | — | — | 1 | 7.43 |
| CHEMBL2178282 | — | — | 1 | 7.32 |
| CHEMBL2178289 | — | — | 1 | 7.25 |
| CHEMBL849 | TRICLOSAN | 4.0 | 1 | 7.23 |
| CHEMBL2178285 | — | — | 1 | 7.09 |
| CHEMBL2178288 | — | — | 1 | 6.75 |
| CHEMBL2178283 | — | — | 1 | 4.68 |
| CHEMBL2178290 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178304 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2178284 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2178291 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2178287 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2178286 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2178305 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2178303 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2178282 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL2178289 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL849 | TRICLOSAN | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL2178285 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL2178288 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2178283 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL2178290 | — | IC50 | > | 100000.0 | nM | - |