Assay Detail
Binding
CHEMBL2188200
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Displacement of radioligand from human 5HT4R by Cerep protocol based assay
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-affinity relationships of selective high-affinity 5-HT(4) receptor antagonists: application to the design of new potential single photon emission computed tomography tracers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 9.79 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2181170 | — | — | 2 | 10.40 |
| CHEMBL2181166 | — | — | 1 | 9.64 |
| CHEMBL2181168 | — | — | 1 | 9.59 |
| CHEMBL2181169 | — | — | 1 | 8.92 |
| CHEMBL2181167 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2181170 | — | Ki | = | 0.03981 | nM | 10.40 |
| CHEMBL2181170 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL2181166 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL2181168 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL2181169 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL2181167 | — | Ki | - | — | - |