Assay Detail
Binding
CHEMBL2188464
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant HDAC6 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.68 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.92 |
| CHEMBL2179249 | — | — | 1 | 8.62 |
| CHEMBL2179618 | NEXTURASTAT A | — | 1 | 8.30 |
| CHEMBL2179615 | — | — | 1 | 8.24 |
| CHEMBL2179617 | — | — | 1 | 8.03 |
| CHEMBL2179616 | — | — | 1 | 7.93 |
| CHEMBL2179619 | — | — | 1 | 7.85 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 7.82 |
| CHEMBL2179244 | — | — | 1 | 7.60 |
| CHEMBL2179246 | — | — | 1 | 7.39 |
| CHEMBL2179245 | — | — | 1 | 7.22 |
| CHEMBL2179247 | — | — | 1 | 6.86 |
| CHEMBL2179248 | — | — | 1 | 6.34 |
| CHEMBL2179250 | — | — | 1 | 6.33 |
| CHEMBL272980 | MOCETINOSTAT | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2179249 | — | IC50 | = | 2.38 | nM | 8.62 |
| CHEMBL2179618 | NEXTURASTAT A | IC50 | = | 5.02 | nM | 8.30 |
| CHEMBL2179615 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL2179617 | — | IC50 | = | 9.26 | nM | 8.03 |
| CHEMBL2179616 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL2179619 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2179244 | — | IC50 | = | 25.2 | nM | 7.60 |
| CHEMBL2179246 | — | IC50 | = | 41.1 | nM | 7.39 |
| CHEMBL2179245 | — | IC50 | = | 60.3 | nM | 7.22 |
| CHEMBL2179247 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL2179248 | — | IC50 | = | 458.0 | nM | 6.34 |
| CHEMBL2179250 | — | IC50 | = | 468.0 | nM | 6.33 |
| CHEMBL272980 | MOCETINOSTAT | IC50 | > | 10000.0 | nM | - |