Assay Detail
Binding
CHEMBL2188465
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant HDAC1 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.84 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.30 |
| CHEMBL272980 | MOCETINOSTAT | 2.0 | 1 | 6.99 |
| CHEMBL2179247 | — | — | 1 | 6.58 |
| CHEMBL2179246 | — | — | 1 | 5.87 |
| CHEMBL2179245 | — | — | 1 | 5.87 |
| CHEMBL2179615 | — | — | 1 | 5.77 |
| CHEMBL2179249 | — | — | 1 | 5.72 |
| CHEMBL2179617 | — | — | 1 | 5.65 |
| CHEMBL2179248 | — | — | 1 | 5.59 |
| CHEMBL2179618 | NEXTURASTAT A | — | 1 | 5.52 |
| CHEMBL2179619 | — | — | 1 | 5.51 |
| CHEMBL2179616 | — | — | 1 | 5.29 |
| CHEMBL2179244 | — | — | 1 | 5.09 |
| CHEMBL2179250 | — | — | 1 | 5.05 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL272980 | MOCETINOSTAT | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL2179247 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL2179246 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL2179245 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL2179615 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL2179249 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL2179617 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL2179248 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL2179618 | NEXTURASTAT A | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL2179619 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL2179616 | — | IC50 | = | 5180.0 | nM | 5.29 |
| CHEMBL2179244 | — | IC50 | = | 8120.0 | nM | 5.09 |
| CHEMBL2179250 | — | IC50 | = | 8950.0 | nM | 5.05 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 16400.0 | nM | 4.79 |