Assay Detail
Functional
CHEMBL2188499
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human FADU cells incubated for 72 hrs by MTT assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | FaDu |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural optimization and structure-activity relationships of N2-(4-(4-Methylpiperazin-1-yl)phenyl)-N8-phenyl-9H-purine-2,8-diamine derivatives, a new class of reversible kinase inhibitors targeting both EGFR-activating and resistance mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.56 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178352 | — | — | 1 | 7.82 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178352 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL939 | GEFITINIB | IC50 | = | 50.0 | nM | 7.30 |