Assay Detail
Binding
CHEMBL2188685
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Binding affinity to Bcl-2 after 30 mins by florescence polarization assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
An anthraquinone scaffold for putative, two-face Bim BH3 α-helix mimic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.71 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180320 | — | — | 1 | 7.62 |
| CHEMBL2180318 | — | — | 1 | 7.36 |
| CHEMBL2180319 | — | — | 1 | 7.15 |
| CHEMBL2180317 | — | — | 1 | 7.06 |
| CHEMBL2180321 | — | — | 1 | 6.88 |
| CHEMBL2180322 | — | — | 1 | 6.38 |
| CHEMBL192032 | — | — | 1 | 6.23 |
| CHEMBL55814 | ATHRAQUINONES A | — | 1 | 5.94 |
| CHEMBL372711 | XANTHOPURPURIN | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180320 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL2180318 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL2180319 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL2180317 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL2180321 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL2180322 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL192032 | — | Ki | = | 583.0 | nM | 6.23 |
| CHEMBL55814 | ATHRAQUINONES A | Ki | = | 1150.0 | nM | 5.94 |
| CHEMBL372711 | XANTHOPURPURIN | Ki | = | 1700.0 | nM | 5.77 |