Assay Detail
Binding
CHEMBL2188686
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Binding affinity to Mcl-1 after 30 mins by florescence polarization assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
An anthraquinone scaffold for putative, two-face Bim BH3 α-helix mimic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.81 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180320 | — | — | 1 | 7.89 |
| CHEMBL2180318 | — | — | 1 | 7.42 |
| CHEMBL2180319 | — | — | 1 | 7.28 |
| CHEMBL2180317 | — | — | 1 | 7.25 |
| CHEMBL2180321 | — | — | 1 | 6.97 |
| CHEMBL192032 | — | — | 1 | 6.57 |
| CHEMBL2180322 | — | — | 1 | 6.51 |
| CHEMBL55814 | ATHRAQUINONES A | — | 1 | 5.79 |
| CHEMBL372711 | XANTHOPURPURIN | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180320 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL2180318 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL2180319 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL2180317 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL2180321 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL192032 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL2180322 | — | Ki | = | 312.0 | nM | 6.51 |
| CHEMBL55814 | ATHRAQUINONES A | Ki | = | 1620.0 | nM | 5.79 |
| CHEMBL372711 | XANTHOPURPURIN | Ki | = | 2270.0 | nM | 5.64 |