Assay Detail
Functional
CHEMBL2188775
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against human mineralocorticoid receptor expressed in CHOK1 cells after 10 to 30 mins by luciferase reporter gene assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mineralocorticoid receptor antagonists for the treatment of hypertension and diabetic nephropathy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.68 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2181927 | FINERENONE | 4.0 | 1 | 7.80 |
| CHEMBL2181926 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2181927 | FINERENONE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2181926 | — | IC50 | = | 28.0 | nM | 7.55 |