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Assay Detail

CHEMBL2188787

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at rat P2Y1R assessed as glucose-dependent insulin secretion
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

P2Y purinoceptor 1 (CHEMBL2497)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Identification of a promising drug candidate for the treatment of type 2 diabetes based on a P2Y(1) receptor agonist.
Yelovitch S, Barr HM, Camden J, Weisman GA, Shai E, Varon D, Fischer B.
J Med Chem (2012) 55 : 7623 -7635
PubMed 22873688 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 7.55 7.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2181943 1 7.55

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2181943 EC50 = 28.1 nM 7.55