Assay Detail
Binding
CHEMBL2188994
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of porcine brain CK1delta/epsilon using RRKHAAIGpSAYSITA as substrate and [gamma-33P]-ATP after 30 mins by scintillation counting
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.76 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180854 | — | — | 1 | 5.89 |
| CHEMBL2180844 | — | — | 1 | 5.82 |
| CHEMBL2180858 | — | — | 1 | 5.58 |
| CHEMBL2180845 | — | — | 1 | - |
| CHEMBL2180843 | — | — | 1 | - |
| CHEMBL2180859 | — | — | 1 | - |
| CHEMBL2180857 | — | — | 1 | - |
| CHEMBL2180856 | — | — | 1 | - |
| CHEMBL2180855 | — | — | 1 | - |
| CHEMBL2180853 | — | — | 1 | - |
| CHEMBL2180852 | — | — | 1 | - |
| CHEMBL2180862 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180854 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2180844 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2180858 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2180845 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL2180843 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2180859 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2180857 | — | IC50 | - | — | - | |
| CHEMBL2180856 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2180855 | — | IC50 | - | — | - | |
| CHEMBL2180853 | — | IC50 | - | — | - | |
| CHEMBL2180852 | — | IC50 | - | — | - | |
| CHEMBL2180862 | — | IC50 | - | — | - |